146 articles - From Friday Jul 25 2025 to Friday Aug 01 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
|---|
The EXTENT Study: Results from an International Expert Delphi Consensus to define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn's Disease. Ultrasonographic equivalents for assessing small bowel and colonic damage in CD were derived to align with the validated LI criteria for MRE and colonoscopy. These statements mark the first phase of the EXTENT project, supporting the potential use of IUS in clinical practice and disease modification trials as an alternative tool for bowel damage assessment. The lack of consensus on grade 1 stricturing lesions suggests further exploration of IUS parameters is required. |
| Gastrointest Endosc |
Association for Bariatric Endoscopy systematic review and meta-analysis assessing the American Society for Gastrointestinal Endoscopy preservation and incorporation of valuable endoscopic innovations thresholds for transoral outlet reduction. For suturing TORe, the pursestring suture pattern appears to be associated with superior outcomes compared to other suturing techniques. This PIVI assessment will be updated as additional data become available. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
Network Meta-Analysis: Comparative Efficacy of Biologics and Small Molecules in the Induction and Maintenance of Remission in Crohn's Disease. Novel IL-23 inhibitors (such as mirikizumab, risankizumab and guselkumab) and anti-TNFs (such as infliximab and adalimumab) ranked high in the induction of clinical and endoscopic remission. This highlights the potential of novel advanced therapies for CD. |
| Clin Gastroenterol Hepatol |
Early prognostic factors for reduced survival in autoimmune hepatitis: a systematic review with meta-analysis. Cirrhosis and insufficient treatment response are the prognostic factors with the highest impact on reduced survival in AIH. Other risk factors include advanced age, non-Caucasian ethnicity, PSC-variant syndrome, asymptomatic presentation, higher relapse rates and elevated INR, creatinine, ALP/AST ratio, and MELD score, while elevated baseline aminotransferases and albumin are protective. |
Efficacy of Advanced Therapies in Achieving Remission by Disease Location in Crohn's Disease: A Systematic Review and Meta-analysis. The magnitude of efficacy of advanced therapies for ileal CD is generally lower compared with isolated colonic CD, with JAK inhibitors showing particularly limited efficacy for ileal disease. These results may help inform treatment selection. |
Global Trends in Antimicrobial Resistance Among Cirrhosis Patients with Bacteremia: A Systematic Review and Meta-Analysis. Bacteremia poses a significant global burden in cirrhosis, with geographic variability in AMR patterns. These findings highlight the urgent need for region-specific infection control, antibiotic stewardship, and enhanced AMR surveillance. |
| Gastrointest Endosc |
Clinical outcomes of EUS-guided gallbladder drainage in patients with acute cholecystitis with ≥1 year of follow-up: a systematic review and meta-analysis. This study demonstrates that EUS-GBD is a technically effective and clinically durable treatment modality for acute cholecystitis with over one year follow up duration. The overall low rate of AEs associated with EUS-GBD reflects its unique ability to care for individuals considered high risk for surgery. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Emerging Trends in Patients Hospitalised With Cirrhosis-Aetiologies, Complications and Outcomes Compared to Other Chronic Health Conditions. Cirrhosis remains a significant clinical and public health challenge and is falling behind other major comorbidities with regard to inpatient outcomes. A focus on improved resource allocation and management options is warranted. |
Liver Fibrosis and the Risk of Coronary Artery Disease, Stent Thrombosis, Restenosis and Adverse Clinical Outcomes. Over 14.4 years, FIB-4 > 2.67 was associated with higher CAD incidence (aHR = 1.41, p 2.67 was associated with increased risks of ST and ISR (aHR = 1.34, p = 0.001) and MACE (aHR = 1.97, p < 0.001). Liver fibrosis is common among patients with CAD and is associated with CAD incidence, stent thrombosis, restenosis and long-term cardiovascular risk. |
| Am J Gastroenterol |
Diagnosing Wilson Disease in Acute Liver Failure: Comparison of existing and experimental biomarkers. Standard biochemistry provides excellent diagnostic information for identifying WD in the setting of ALF. Combining ALT with specific copper measurements significantly improved diagnostic utility, with ANCC outperforming s-Cu. RelANCC may also be useful for WD diagnosis. We suggest adding s-Cu to the clinical algorithm in ALF. |
Epidemiologic Trends in Acute, Chronic, and Pregnancy-Specific Liver Diseases in Pregnancy. In this large epidemiologic study, we observed a 2.5-fold rise in CLD in pregnancy over the past 10 years, largely driven by the rising prevalence of MASLD, and declining prevalence of chronic viral hepatitis. Pregnancy-specific liver conditions were also significantly more common in those with CLD. Findings underscore the relevance of pre-conception counseling by hepatology providers and the importance of early obstetric collaboration to optimize outcomes for the growing number of pregnant women with pre-existing liver disease. |
Inflammatory Bowel Diseases-Specific Cognitive Behavioral Therapy Delivered via Telehealth Reduces Disability: ADEPT (Addressing Disability Effectively with Psychosocial Telemedicine) Pragmatic Randomized Controlled Trial. In a randomized controlled trial of patients with IBD, an 8-week telehealth-delivered IBD-specific CBT protocol reduced IBD-related disability, independent of clinical disease activity. |
Inflammatory bowel disease and risk of more than 1500 comorbidities: A disease-wide pre- and post-diagnostic phenomic association study. Findings demonstrate that IBD is a multisystemic disease, particularly manifesting with metabolic, immune, and neuropsychological disorders, up-to 10 years prior to diagnosis. We find evidence for the generality of these findings with an international comparison. Diseases of etiological interest warrant further investigation. |
Intraductal Papillary Mucinous Neoplasm and Pancreatic Cancer: Opportunity Knocks Twice. This review highlights current evidence and future perspectives on the clinical management of patients with IPMNs, with a particular focus on the dual opportunities for surveillance. Optimizing strategies for the early detection of both carcinoma derived from IPMN and carcinoma concomitant with IPMN has the potential to meaningfully reduce the burden of pancreatic cancer. |
Lifestyle change after initial colonoscopy screening and incidence of colorectal cancer and major chronic diseases. Adopting a healthier lifestyle after initial colonoscopy screening may reduce risk of CRC and chronic diseases, suggesting colonoscopy screening could be a teachable moment for health promotion. |
Measuring the Risk of Gluten Exposure: Development of the Gluten Exposure Risk Assessment (GERA) in Pediatric Patients. The Gluten Exposure Risk Assessment is a valid screening measure, completed by caregivers, for assessment of gluten exposure in children and adolescents with CeD following a gluten-free diet. GERA is a useful tool for evaluating the potential of risk for gluten exposure and potential need for intervention. |
Novel Implementation of Hepatitis B to Hepatitis Delta Reflex Testing in a United States Healthcare System. Reflex testing improved efficiency and reduced gaps in the HBsAg to HDV screening cascade. Disparities in reflex testing rates among different patient groups were found, highlighting the need for universal reflex testing. |
Recurrence of primary sclerosing cholangitis after liver transplantation: a French national cohort study including 571 patients. Our results from a large cohort with long-term follow-up strongly confirm that rPSC after LT is frequent. The only modifiable factor associated with rPSC was maintenance treatment with corticosteroids, which could therefore be discontinued in the absence of a specific extra-hepatic indication. |
Simvastatin addition to standard of care improves long-term survival in patients with cirrhosis after variceal bleed: An open label randomized controlled trial. Simvastatin may be associated with improved survival in selected patients with cirrhosis after variceal bleed and reduced incidence of new onset/refractory ascites and its complications [CTRI/2022/07/044263]. |
The Patients Included in Clinical Trials of Biological Drugs for Inflammatory Bowel Disease Do Not Represent the Real-World Population. Only a minority of real-world IBD patients would qualify for corresponding RCTs, questioning the external validity of these trials. However, real-world use of biologics demonstrated similar effectiveness and safety in eligible and non-eligible patients, underscoring the importance of practical clinical judgement in therapeutic decisions. |
| Clin Gastroenterol Hepatol |
Comparative Safety of Janus Kinase inhibitors vs. Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases. In an observational study of patients with IBD, JAK inhibitors were not associated with an increased risk of serious infections, VTE, or MACE compared with TNF antagonists, though the overall risk of infections was higher. |
FIB-4 BASED REFERRAL PATHWAYS HAVE SUBOPTIMAL ACCURACY TO IDENTIFY INCREASED LIVER STIFFNESS AND INCIDENT ADVANCED LIVER DISEASE. FIB-4-based referral pathways to identify liver disease among the general population result in a high referral rate whilst not detecting approximately 60% of LSM≥8, 50% of LSM≥12, 40% of LSM≥15 and 25% of incident advanced liver disease. Current referral pathways to detect pre-cirrhotic liver disease in low-prevalence populations could benefit from further optimization. |
Impact of inflammatory bowel disease and primary sclerosing cholangitis on colorectal cancer risk:national cohort study. IBD patients have an increased risk of CRC, mostly prominent among young PSC+ patients. PSC+ patients display a tendency to develop CRC in the proximal colon and more synchronous CRC. This should be considered when monitoring and counselling IBD patients. |
Multi-Center Validation of Video-Based Deep Learning to Evaluate Defecation Patterns on 3D High-Definition Anorectal Manometry. 3D high-definition anorectal manometry combined with video-based deep learning is a useful and clinically relevant technology for evaluating anorectal dyssynergia. Future use cases can be expanded to evaluating other motility disorders and their treatment. |
NEOPLASIA DETECTION RATE AND RISK OF POST-ENDOSCOPY ESOPHAGEAL ADENOCARCINOMA AND NEOPLASIA IN A POPULATION-BASED COHORT STUDY. This study has provided population-based estimates of CDR and NDR and associations between CDR/NDR and PEEC/PEEN. Future studies remain to determine whether improving CDR/NDR decrease the incidence of PEEC/PEEN. |
Preoperative body composition parameters are associated with postoperative outcomes in patients with Crohn's disease. Preoperative myosteatosis was consistently associated with overall postoperative complications, moderate-to severe, and infectious complications, in patients with CD following ICR. Furthermore, several body composition parameters were identified as risk factor or protective factor for postoperative complications and ePOR. Inconsistent findings were observed for SM levels and ePOR risk. The correlation between improvements of these parameters and postoperative outcomes requires further study. |
The Real-World Impact of Vitamin D Supplementation on Inflammatory Bowel Disease Clinical Outcomes. Vitamin D supplementation was associated with reduced IBD-related ED visits, hospitalizations, and corticosteroid use, supporting its potential as a low-cost adjunct in IBD management. Prospective studies are needed to optimize dosing strategies and define target serum levels for improved long-term outcomes. |
Upadacitinib Maintenance Therapy in Crohn's Disease: Final Results From the Randomized Phase 3 U-ENDURE Study. Consistent with the primary analysis, upadacitinib was more efficacious than placebo in achieving clinical and endoscopic endpoints in patients with Crohn's disease. The safety profile remained consistent with no new safety signals. Number NCT03345823. |
| Endosc Int Open |
Do all trainers think the same? Exploring use of the Think Aloud method to understand colonoscopy trainer thought processes. This study provides support for use of TA as a method to understand trainer cognition in colonoscopy. It suggests the need for further research to explore consistency of training across trainers. |
Endoscopic ultrasound-guided gallbladder drainage for distal malignant biliary obstruction: Outcomes from a multicenter cohort. EUS-GBD is a clinically effective salvage therapy for DMBO that may be positioned after unsuccessful endoscopic retrograde cholangiopancreatography or EUS-BD in a single anesthetic session. Most patients have a short LOS and few serious AEs. Furthermore, oncologic therapy can be successfully resumed post-procedure. EUS-GBD, therefore, should be considered an effective, safe, and durable addition to the treatment armamentarium for DMBO. |
Financial buy-in does not affect outcomes of endoscopic sleeve gastroplasty: Retrospective cohort. Having "skin in the game" by paying for ESG OOP does not correlate with better outcomes or treatment adherence, which further supports broad insurance coverage for this procedure. |
Minor papilla approach improves technical success of nasopancreatic drainage-based pancreatic juice cytology for early pancreatic cancer diagnosis. Incorporating the minor papilla approach substantially improves technical success of NPD-PJC without increasing PEP risk, underscoring the importance of individualized ERP strategies for early-stage PC diagnosis. |
Outcomes and complications of biliary drainage for malignant biliary obstruction: National prospective study. Careful multidisciplinary consideration of risks and potential benefits should be undertaken prior to attempting malignant biliary drainage due to the high risk of complications and early mortality. |
Pathologic complete response after neoadjuvant therapy for resectable esophageal squamous cell carcinoma: Endoscopic characteristics and implications. Endoscopic characteristics are significant predictors of pCR in patients with ESCC receiving nCIT or nCT. The predictive model demonstrated high accuracy in both derivation and validation cohorts. |
| Endoscopy |
Adverse events of cold snare compared to hot snare and ablation endoscopic mucosal resection for large colorectal polyps. Cold EMR demonstrated lower rates of SAEs, serious PEB and perforation compared to hot EMR. Perforation and mortality occurred almost exclusively after hot EMR. Hot EMR with margin ± base ablation did not increase SAEs compared to hot EMR without ablation. |
Regenerative endoscopy for the treatment of difficult gastrointestinal defects: results from a pilot trial. These results suggest that endoscopic injection of autologous tSVFem may treat complex esophageal and rectal defects, also communicating with adjacent organs other than the urinary tract. (ClinicalTrials.gov, number NCT04670276). |
Topical hemostatic agents in endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review. Topical hemostatic agents offer effective options for managing GI bleeding. Products like Purastat, TC-325 Hemospray, EndoClot PHS, Nexpowder, Ankaferd Blood Stopper, and CG GEL have shown promising results in achieving hemostasis; however, further RCTs and cost-effectiveness analyses are needed to better establish their roles in endoscopic practice. |
| Gastroenterology |
Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation. Random forest analysis trained on a global prospective cirrhosis cohort enhances mortality prediction over traditional methods, is consistent across country income levels, and is successfully validated externally in a US-Veteran population. |
| Gastrointest Endosc |
Clinical Outcomes of Endoscopic Submucosal Dissection for Residual Neoplasia After Incomplete Resection of Large Non-Pedunculated Colorectal Polyps: A Large Multicenter Propensity Match Study. ESD can be performed safely and effectively as a salvage therapy after failed attempt at ER of LNPCPs. ESD may be selectively considered as part of our endoscopic armamentarium for the management of these difficult-to-treat lesions. support current guideline endorsed indications for ESD for the treatment of residual neoplasia after incomplete ER. |
| Gut |
Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies. This study evaluated the broader applicability of the China-CLIF framework across diverse aetiologies and varying severity levels of ACLF. These findings may provide a valuable foundation for harmonising ACLF diagnostic and prognostic system. |
Real-world impact of implementing lumen-apposing metal stents for pancreatic fluid collections: a nationwide Japanese study. The implementation of LAMS was not associated with improved key clinical outcomes but was linked to a higher risk of bleeding and increased healthcare costs. These findings do not support the routine use of LAMS for EUS-guided treatment of al PFCs in standard clinical practice but may restrict it to WON cases with clear indications. |
Targeting Aurora kinase B regulates cholesterol metabolism and enhances chemoimmunotherapy in cholangiocarcinoma. AURKB inhibitor or simvastatin can suppress CCA progression and significantly enhance sensitivity to chemoimmunotherapy. AURKB regulates cholesterol levels and immune microenvironment in tumours, highlighting that targeting AURKB or adopting cholesterol-reducing strategy holds promise for CCA treatment, especially in conjunction with first-line chemoimmunotherapy. |
| Hepatology |
Chiglitazar in MASLD with hypertriglyceridemia and insulin resistance: A phase II, randomized, double-blind, placebo-controlled study. Chiglitazar significantly reduced liver fat content in MASLD with hypertriglyceridemia and insulin resistance, with a dose-dependent effect and favorable safety profile. |
E2F2 transcription factor promotes a cholestatic MASH phenotype by regulating hepatobiliary metabolism through miR-34a-5p. E2F2 deficiency protects against MASH and cholestasis preventing cholesterol accumulation, fibrosis, and inflammation through modulation of miR-34a-5p, which could provide therapeutic benefits for patients with cholestatic-MASH. |
| J Neurogastroenterol Motil |
Amitriptyline for the Treatment of Extra-esophageal Symptoms in Proton Pump Inhibitor-refractory Patients With Suspected Gastroesophageal Reflux Disease. Adding low-dose amitriptyline to PPI therapy did not offer a short-term advantage over PPI alone. Both treatments improved symptoms and QoL. Given the challenging nature of GERD's extraesophageal manifestations and mixed evidence for neuromodulator therapy, further studies are needed to identify patient subgroups that may benefit from adjunctive neuromodulator therapy. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
Advancing Inflammatory Bowel Disease-driven Colorectal Cancer Management: Molecular Insights and Endoscopic Breakthroughs Towards Precision Medicine. The future of IBD-related CRC management will incorporate a holistic, multi-integrated approach, combining AI-driven diagnostics, omics data integration, endoscopic and surgical innovations and nanotechnology-based therapies. This paradigm shift aims to enhance precision medicine, promoting organ-sparing approaches, improved diagnostics, and personalized cancer treatment with the potential to reduce CRC risk. |
| Endosc Int Open |
Colon capsule endoscopy today: Brief overview of leading UK and Danish initiatives. These national CCE programs reveal the complexity of large-scale implementation, driven by variations in definitions and protocols. Harmonized quality metrics and shared definitions of success are essential. Efforts should focus on reducing downstream procedures and fostering cross-system learning. |
| Gastroenterology |
| Gut |
Recent advances in clinical practice endohepatology: the endoscopic liver rush. These involve, among others, endoscopic ultrasound (EUS)-guided liver biopsy, EUS-guided portal pressure gradient measurement, coil and glue embolisation of gastric varices and spontaneous portosystemic shunts, artificial-assisted cholangioscopy. In this review, we aim to focus on different applications within endohepatology which are at the benchtop (or coming close by) and attempt to prognosticate potential future techniques within this rapidly evolving field. |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Gastroenterology |
| Gastrointest Endosc |
| Gut |